Any idea why I'm getting this trying to publish to host server running in the full trust?

[SecurityException: Request for the permission of type 'System.Security.Permissions.ReflectionPermission, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089' failed.]
   System.Security.CodeAccessSecurityEngine.Check(Object demand, StackCrawlMark& stackMark, Boolean isPermSet) +0
   System.Security.CodeAccessSecurityEngine.Check(CodeAccessPermission cap, StackCrawlMark& stackMark) +31
   System.Security.CodeAccessPermission.Demand() +46
   System.Reflection.Emit.DynamicMethod.PerformSecurityCheck(Type owner, StackCrawlMark& stackMark, Boolean skipVisibility) +9461551
   System.Reflection.Emit.DynamicMethod..ctor(String name, Type returnType, Type[] parameterTypes, Type owner, Boolean skipVisibility) +40
   AutoMapper.DelegateFactory.CreateDynamicMethod(MemberInfo member, Type sourceType) +585
   AutoMapper.DelegateFactory.CreateSet(PropertyInfo property) +128
   AutoMapper.Internal.PropertyAccessor..ctor(PropertyInfo propertyInfo) +122
   AutoMapper.ReflectionHelper.ToMemberAccessor(MemberInfo accessorCandidate) +294
   AutoMapper.TypeMapFactory.CreateTypeMap(Type sourceType, Type destinationType, IMappingOptions options) +521
   AutoMapper.Configuration.CreateTypeMap(Type source, Type destination, String profileName) +156
   AutoMapper.Configuration.CreateMap(String profileName) +179
   AutoMapper.Configuration.CreateMap() +92
   AutoMapper.Mapper.CreateMap() +99
   Gallery.Infrastructure.Impl.AutoMapperBootstrapper.RegisterMappings() in AutoMapperBootstrapper.cs:23
   Gallery.Server.Global.Application_Start(Object sender, EventArgs e) in Global.asax.cs:17

I've never seen that exception before. We do use AutoMapper in the Gallery Server code, which obviously uses reflection, but I don't think you should be getting that if you're running in full trust. Do you have your IIS app pool running ASP.Net 4.0 or 2.0?  (It should be 4.0)

iis 7 .net 4 integrated full trust (internal). Do you have any suggestions on deploying it outside VS? xcopy? webdeploy? Do I need make any configuration changes? It seems to have a whole lot of "localhost" references. Xcopy definitely did not work for me on two different host servers, will try webdeploy now.

Ok, here is what worked in the end:

1. Web deploy from WebMatrix to supported host. Still was getting security exceptions.

2. Set full trust in web.config. Most hosts won't let you, so I guess I got lucky here. Still was getting error, this time from activator complaining about multiple authentication methods enabled.

3. In IIS under site's authentication, left only "anonymous" (it also had basic enabled).

After these steps, all seems to work fine.

Glad to hear you got it working. We have not tried Web Deploy yet, but it's good to know that it works. We just manually deployed the site when we launched it. A better deployment story is something that is planned for the future though.